https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 A pro-inflammatory diet in people with multiple sclerosis is associated with an increased rate of relapse and increased FLAIR lesion volume on MRI in early multiple sclerosis: A prospective cohort study https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:51575 Wed 29 May 2024 15:12:23 AEST ]]> Role of genetic susceptibility variants in predicting clinical course in multiple sclerosis: a cohort study https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:29865 Wed 24 Jun 2020 12:59:16 AEST ]]> Sun exposure across the life course significantly modulates early multiple sclerosis clinical course https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:47544 Wed 22 Mar 2023 15:52:30 AEDT ]]> The association between disability progression, relapses, and treatment in early relapse onset MS: an observational, multi-centre, longitudinal cohort study. https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:54897 Wed 20 Mar 2024 13:32:33 AEDT ]]> Variation within MBP gene predicts disease course in multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:34728 interaction = 0.05) and relapse (pinteraction = 0.02). Functional prediction analysis showed this variant is the target of many transcription factors and the binding sites of miR-218 and miR-188-3p. Conclusions: Our results provide novel insights into the role of genetic variation within the MBP gene predicting MS clinical course, both directly and by interaction with known environmental MS risk factors.]]> Wed 04 Sep 2019 10:04:21 AEST ]]> Estimation of annual probabilities of changing disability levels in Australians with relapsing-remitting multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:47837 n = 330), annual transition probabilities were obtained between no/mild (Expanded Disability Status Scale (EDSS) levels 0-3.5), moderate (EDSS 4-6.0) and severe (EDSS 6.5-9.5) disability. Results: From no/mild disability, 6.4% (95% confidence interval (CI): 4.7-8.4) and 0.1% (0.0-0.2) progressed to moderate and severe disability annually, respectively. From moderate disability, 6.9% (1.0-11.4) improved (to no/mild state) and 2.6% (1.1-4.5) worsened. From severe disability, 0.0% improved to moderate and no/mild disability. Male sex, age at onset, longer disease duration, not using immunotherapies greater than 3 months and a history of relapse were related to higher probabilities of worsening. Conclusion: We have estimated probabilities of changing disability levels in Australians with RRMS. Probabilities differed between various subgroups, but due to small sample sizes, results should be interpreted with caution. Our findings will be helpful in predicting long-term disease outcomes and in health economic evaluations of MS.]]> Wed 01 Feb 2023 15:34:54 AEDT ]]> The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: A systematic review https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:39853 Tue 26 Jul 2022 10:28:34 AEST ]]> DNA Methylation Signatures of Multiple Sclerosis Occur Independently of Known Genetic Risk and Are Primarily Attributed to B Cells and Monocytes https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:54378 Tue 20 Feb 2024 20:24:50 AEDT ]]> Interferon beta treatment is a potent and targeted epigenetic modifier in multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:52582 Tue 17 Oct 2023 15:55:43 AEDT ]]> Common genetic variation within miR-146a predicts disease onset and relapse in multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:43091 Tue 13 Sep 2022 12:26:49 AEST ]]> Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: a multicentre Australian cohort study https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:34120 Tue 12 Feb 2019 13:13:57 AEDT ]]> HLA-DRB1*15:01 and the MERTK Gene Interact to Selectively Influence the Profile of MERTK-Expressing Monocytes in Both Health and MS https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:55006 Thu 28 Mar 2024 13:52:11 AEDT ]]> Onset symptoms, Tobacco smoking, and progressive-onset phenotype are associated with a delayed onset of multiple sclerosis, and marijuana use with an earlier onset https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:43333 Thu 15 Sep 2022 14:57:26 AEST ]]> Associations between silicone skin cast score, cumulative sun exposure, and other factors in the Ausimmune study: a multicenter Australian study https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:7617 10 sunburns ever compared with no sunburns ever). Silicone casts of the dorsum of the hand provide a measure of cumulative UVR dose and number of sunburns over the lifetime, which persists after adjustment for chronological age. They can be used as an objective measure of cumulative past sun exposure in epidemiologic studies, but other determinants of skin damage, such as skin pigmentation, should be concurrently evaluated.]]> Sat 24 Mar 2018 08:34:44 AEDT ]]> Latitudinal variation in incidence and type of first central nervous system demyelinating events https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:10630 Sat 24 Mar 2018 08:13:48 AEDT ]]> Evaluation of Cell-Specific Epigenetic Age Acceleration in People With Multiple Sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:53246 Mon 20 Nov 2023 10:14:36 AEDT ]]> Long-term trajectories of employment status, workhours and disability support pension status, after a first episode of CNS demyelination https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:51774 Mon 18 Sep 2023 14:29:20 AEST ]]> Ensemble machine learning identifies genetic loci associated with future worsening of disability in people with multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:52379 Mon 01 Jul 2024 10:27:10 AEST ]]> Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:53931 Fri 22 Mar 2024 08:23:10 AEDT ]]> Developing a clinical-environmental-genotypic prognostic index for relapsing-onset multiple sclerosis and clinically isolated syndrome https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:49201 Fri 05 May 2023 15:58:23 AEST ]]>